How is the quality of the available evidence on molar-incisor hypomineralization treatment? An overview of systematic reviews.

OBJECTIVE: This overview analyzed the quality of the systematic reviews (SRs) available on treatments for molar-incisor hypomineralization (MIH). MATERIAL AND METHODS: Six electronic databases were searched (PubMed/MEDLINE, Scopus, Web of Science, LILACS, Brazilian Bibliography of Dentistry and Cochrane Library) until March 2022. Two reviewers independently performed the selection, the quality assessment (Assessment of Multiple Systematic Reviews 2 - AMSTAR-2), and the risk of bias assessment of the SR (Risk of Bias in Systematic Reviews - ROBIS). RESULTS: Two hundred nine records were retrieved; after removing duplicates and applying the inclusion/exclusion criteria, 5 SRs remained. Three SRs were rated as showing critically low methodological quality and high risk of bias, and two were rated as moderate methodological quality and low risk of bias. The identified treatments that may be suitable for MIH were classified as (1) non-invasive - casein incorporated into toothpaste and sugar-free chewing gum, toothpaste containing arginine, 0.4% stannous fluoride gel; fluoride varnish; (2) micro-invasive - resin sealants for pits and fissures, microabrasion, dental whitening, resin infiltration; (3) invasive - ART restorations, indirect restorations (metal, composite, or ceramic); and (4) mixed intervention - stainless steel crowns. CONCLUSION: Despite the considerable number of published papers included in this set of systematic reviews, the evidence supporting the effectiveness of treatments for treating MIH is limited due to the methodological quality and risk of bias of the systematic reviews, as well as the quality of the primary studies (PROSPERO: CRD42020144831). CLINICAL RELEVANCE: Different treatments have been purposed for MIH treatment, but there is still not enough scientific evidence of good quality for the establishment of a definitive clinical protocol for the treatment of MIH.

Effectiveness of iodoform-based filling materials in root canal treatment of deciduous teeth: a systematic review and meta-analysis.

Introduction: The objective was to review the effectiveness of iodoform-based compared to noniodoform-based filling materials in the root canal treatment of deciduous teeth. Methods: This systematic review and meta-analysis used randomized clinical trials with six months or more follow-up. The risk of bias of individual studies and the certainty of the evidence were evaluated (Cochrane risk of bias tool and GRADE, respectively). Results: The initial search resulted in 5,127 studies after removal of duplicates. After screening by title and abstract, 34 full-text studies were eligible and 21 remained in the qualitative synthesis and 19 in the meta-analysis. Iodoform-based filling materials resulted in fewer clinical failures when compared to noniodoform-based filling materials at the 6 months (OR = 0.43, 95%CI: 0.19-0.97, p = .04) and 9-12 months (OR = 0.46, 95%CI: 0.23-0.93, p = .03), but not at the 18-30 months follow-up (OR = 1.08, 95%CI: 0.58-2.03, p = .81). When considering radiographic failures, there was no statistical difference between iodoform-based and noniodoform-based filling materials at the 6 months (OR = 0.72, 95%CI: 0.39-1.32, p = .29) and 18-30 months follow-ups (OR = 1.06, 95%CI: 0.51-2.21, p = .87), but fewer radiographic failures were detected at the 9-12 months follow-up (OR = 0.49, 95%CI: 0.29-0.80, p = .005). Conclusion: Iodoform-based filling materials showed better clinical and radiographic performance when compared to non-iodoform-based filling materials in the short term, and similar performance in the long term. However, most of the studies exhibited unclear or high risk of bias and the overall certainty of the evidence ranged from low to very low. Therefore, new randomized clinical trials must be accomplished to corroborate this conclusion.

Tratamento Restaurador Atraumático: evolução do conhecimento e aceitação entre Cirurgiões-Dentistas da Estratégia Saúde da Família de Ponta Grossa - Paraná, Brasil ao longo de 5 anos / Atraumatic Restorative Treatment: evolution of knowledge and acceptance among Doctor of Dental Surgery of the Family Health Strategy of Ponta Grossa - Paraná, Brazil over 5 years

Objetivo: este estudo avaliou as possíveis modificações no conhecimento teórico/técnico e na aceitação da técnica restauradora atraumática (ART) entre Cirurgiões-Dentistas (CDs) da Estratégia Saúde da Família (ESF) de Ponta Grossa ­ PR, Brasil ao longo de 5 anos. Material e Métodos: foram utilizados dois instrumentos de avaliação: entrevistas em profundidade e questionários semiestruturados, aplicados ao mesmo grupo de 14 CDs que atuam na ESF. Durante este período, houve momentos de capacitação oferecidos pela Secretaria de Saúde do Município e Secretaria de Saúde do Estado. Resultados: Os CDs afirmaram, nas duas etapas da pesquisa, conhecer o ART e julgaram-no útil em Saúde Pública, fazendo uso das restaurações atraumáticas (RA) rotineiramente. Houve modificações nas percepções referentes ao caráter definitivo das RA; na indicação da técnica de acordo com a característica da lesão cariosa e de acordo com a idade do paciente; na utilização do ácido poliacrílico e de agentes de proteção para o cimento de ionômero de vidro (CIV), entre outras. Além disso, os dentistas passaram a reconhecer o CIV como material essencial à técnica e a aceitar a manutenção da dentina cariada. Houve modificação no hábito da leitura científica sobre o ART entre os profissionais avaliados, além do aumento do número de indivíduos que receberam capacitações sobre ART no serviço. Conclusão: concluiu-se que houve modificações positivas no conhecimento teórico/técnico e na aceitação da técnica ART entre os profissionais entrevistados, reconhecendo assim a importância das capacitações oferecidas no serviço

Objective: this study evaluated the possible modifications in the theoretical / technical knowledge and the acceptance of the atraumatic restorative technique (ART) among Doctor of Dental Surgery (DDS) of the Family Health Strategy (FHS) of Ponta Grossa ­ PR, Brazil over 5 years. Material and Methods: for this purpose two instruments were used: in-depth interviews and semi-structured questionnaires, applied to the same group of 14 DDS that work at the FHS. During this period of time, there were moments of empowerment offered by the Health Department of the Municipality and State Health Secretariat. Results: the DDS affirmed, in the two stages of the research, to know the ART and they considered it useful in Public Health, making use of atraumatic restorations (AR) routinely. There were modifications in the perceptions regarding the definitive nature of AR; in the indication of the technique according to the characteristic of the carious lesion and according to the age of the patient; in the use of polyacrylic acid and protective agents for glass ionomer cement (GIC), among others. In addition, dentists have come to recognize GIC as essential material for the technique and to accept the maintenance of carious dentin. There was a change in the habit of scientific reading about ART among the evaluated professionals, in addition to the increase in the number of individuals who received ART training in the service. Conclusion: we can conclude that there were positive changes in the theoretical/ technical knowledge and acceptance of the ART technique among the professionals interviewed, thus acknowledging the importance of the training offered in the service

Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy.

The consumption of low-dose aspirin (LDA) to prevent cardiovascular disease continues to increase worldwide. Consequently, the number of chronic LDA users seeking dental procedures that require complementary acute anti-inflammatory medication has also grown. Considering the lack of literature evaluating this interaction, we analyzed the gastric and renal effects caused by a selective COX-2 inhibitor (etoricoxib) and a non-selective COX-2 inhibitor (ibuprofen) nonsteroidal anti-inflammatory drug (NSAID) in rats receiving chronic LDA therapy. Male Wistar rats were divided into six experimental groups (carboxymethylcellulose (CMC) - vehicle; LDA; LDA + ibuprofen; ibuprofen; LDA + etoricoxib; and etoricoxib) and submitted to long-term LDA therapy with a subsequent NSAID administration for three days by gavage. After the experimental period, we analyzed gastric and renal tissues and quantified serum creatinine levels. The concomitant use of LDA with either NSAID induced the highest levels of gastric damage when compared to the CMC group (F = 20.26, p < 0.05). Treatment with either LDA or etoricoxib alone was not associated with gastric damage. No significant damage was observed on kidney morphology and function (F = 0.5418, p > 0.05). These results suggest that even the acute use of an NSAID (regardless of COX-2 selectivity) can induce gastric damage when combined with the long-term use of low-dose aspirin in an animal model. Additional studies, including clinical assessments, are thus needed to clarify this interaction, and clinicians should be careful of prescribing NSAIDs to patients using LDA.

Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy

Abstract The consumption of low-dose aspirin (LDA) to prevent cardiovascular disease continues to increase worldwide. Consequently, the number of chronic LDA users seeking dental procedures that require complementary acute anti-inflammatory medication has also grown. Considering the lack of literature evaluating this interaction, we analyzed the gastric and renal effects caused by a selective COX-2 inhibitor (etoricoxib) and a non-selective COX-2 inhibitor (ibuprofen) nonsteroidal anti-inflammatory drug (NSAID) in rats receiving chronic LDA therapy. Male Wistar rats were divided into six experimental groups (carboxymethylcellulose (CMC) - vehicle; LDA; LDA + ibuprofen; ibuprofen; LDA + etoricoxib; and etoricoxib) and submitted to long-term LDA therapy with a subsequent NSAID administration for three days by gavage. After the experimental period, we analyzed gastric and renal tissues and quantified serum creatinine levels. The concomitant use of LDA with either NSAID induced the highest levels of gastric damage when compared to the CMC group (F = 20.26, p < 0.05). Treatment with either LDA or etoricoxib alone was not associated with gastric damage. No significant damage was observed on kidney morphology and function (F = 0.5418, p > 0.05). These results suggest that even the acute use of an NSAID (regardless of COX-2 selectivity) can induce gastric damage when combined with the long-term use of low-dose aspirin in an animal model. Additional studies, including clinical assessments, are thus needed to clarify this interaction, and clinicians should be careful of prescribing NSAIDs to patients using LDA.